The Future: A no regrets treatment for all stages of psoriasis and broader inflammatory disease Registration

Pioneering a new safe and well tolerated oral therapy that targets the small intestinal axis

Start Date: March 11, 2022

Start Time: 8:00am EST

Duration:90 Minutes

Abstract:

Chronic inflammation affects billions, and the global inflammation crisis shows no signs of slowing. Evelo is a clinical-stage biotech whose vision is to dramatically improve healthcare by providing safe, well tolerated, convenient and affordable medicines for those billions around the world. Evelo has shown that we are able to harness the small intestinal axis – SINTAX™ – to modulate the body’s immune system.

Please join us for an in-depth conversation on the totality of data from Evelo’s EDP1815 Phase 2 trial in psoriasis and potential of EDP1815, an investigational oral biologic, to address systemic inflammation and deliver long-lasting and clinically meaningful benefit to patients. Recently released data from the post-treatment follow-up portion of the Phase 2 psoriasis trial showed durable and deeper clinical responses. The tolerability and safety data for EDP1815 in the Phase 2 psoriasis trial was comparable to placebo, with the additional finding of no flare or rebound following discontinuation of therapy. With the clinical responses and safety and tolerability results observed in trials involving over 450 patients to-date, EDP1815 is being advanced towards Phase 3 clinical trials

During the event, members of Evelo’s leadership, Bruce Strober, M.D., Ph.D., FAAD, and Clinical Professor of Dermatology at Yale University School of Medicine and Central Connecticut Dermatology Research and Daniel Roling, M.D., Associate Professor of Dermatology at University of Pennsylvania School of Medicine, will discuss the unmet need in the treatment of psoriasis and the potential for SINTAX medicines.

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Speakers

Bruce Strober, M.D., Ph.D., FAAD

Clinical Professor of Dermatology

Yale University School of Medicine and Central Connecticut Dermatology Research

Dr. Strober earned both his medical degree and his doctorate from Columbia University College of Physicians and Surgeons in New York, New York. He completed his residency in dermatology in the Department of Dermatology, New York University School of Medicine in New York, New York. He is board certified by the American Board of Dermatology and a Fellow in the American Academy of Dermatology.

Dr. Strober was the Chair of the University of Connecticut Department of Dermatology from 2015-18. He has served as a Section Editor for the British Journal of Dermatology, and is an ad hoc reviewer for Journal of the American Academy of Dermatology, JAMA Dermatology, British Journal of Dermatology, and Inflammation.

His primary clinical focus is the treatment of moderate-to-severe plaque psoriasis and atopic dermatitis. He is an author on over 190 peer-reviewed journal articles and book chapters.

Current Prominent Roles:

• Scientific Co-Director of the CorEvitas Psoriasis Registry

• Treasurer of the International Psoriasis Council

• Editor-in-Chief of the Journal of Psoriasis and Psoriatic Arthritis

Daniel Roling, M.D.

Clinical Associate Professor

Department of Dermatology, Hospital of the University of Pennsylvania

Dr. Roling earned his medical degree from the University of Pennsylvania School of Medicine. He completed his residency in Dermatology at the Hospital of the University of Pennsylvania, Department of Dermatology in 2001. He is a board certified by the American Board of Dermatology.

Dr. Roling has published and assisted in several articles early in his career but found a greater interest in serving as a clinical medical dermatologist in multiple settings ranging from a large academic medical center to working within community setting. His breadth of experience is demonstrated by his enjoyment of teaching residents at the Hospital of the University of Pennsylvania Department of Dermatology where he both graduated and holds an Associate Clinical Professor title. He teaches, lectures and mentors physicians and residents in other medical disciplines where many shadow him in his academic and community practice setting. As a result, he has received teaching accolades and awards by the residents and fellow physicians, including the ‘Best Doctors’ editions of the community and city publications. Dr. Roling has been asked to discuss topics of interest for forums such as Doctor’s Radio and other medical and business environments.

Dr. Roling has interests in a variety of common dermatological conditions such as Psoriasis and Atopic Dermatitis but enjoys the breadth of the field and is often consulted as an alternate opinion in challenging conditions.