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Programmable Pumps for Compound Delivery in Oncology Research

Live Date:6/16/2021

Duration:60 minutes

Over the past decade, there is increasing interest in establishing a robust mechanistic understanding of the pharmacokinetics–pharmacodynamics (PK–PD) relationship of a given compound and its connection to the anti-tumor efficacy profile.

In this webinar, Christian will describe the validation studies performed in his pharmacology unit in rats and mice. Accurate PK-PD assessment and corresponding antitumor activity were assessed among several drug discovery programs. He provides evidence that the investigation of such compound specific relationships are a pre-requisite for the planning of meaningful efficacy studies in preclinical models and the subsequent translation into patient’s clinical trials.

Taking into account best practices and the 3Rs of animal research (Reduction, Refinement and Replacement), implantable pumps are one of the most effective ways to deliver drugs without interfering with normal animal activity, especially in a group-housed environment. Long term, chronic dosing regimens and quantitative pharmacology for PK-PD may be scheduled and executed with minimal human intervention and animal stress, and in doing so reducing the impact of these important confounding factors. Therefore, data variability will be lower leading to reduction of animal use. Moreover, it should be emphasized that the simultaneous use of complementary novel technologies within the same animal (like radio-telemetry and programmable pumps as described here) will enable advances in the understanding of complex physiological regulation mechanism following pharmacological intervention, possibly leading to improved therapies in the clinic.

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Speakers

Christian Schnell

Associate Director Oncology NIBR

Novartis

Christian joined NOVARTIS (previously CIBA-GEIGY) in 1980, first in Cardiovascular Research followed by Oncology Research since 1994. He was actively involved in the profiling of several compounds that entered the clinical development and reached the market like DIOVAN®, RASILEZ®, GLEEVEC®, ZOMETA®, AFFINITOR® and PIQRAY ®. Christian was one of the first to adapt fully implantable telemetry devices for blood pressure and ECG recordings in conscious unrestrained marmosets (1993), for intraocular pressure measurements in the vitreous of conscious unrestrained rabbits (1996), and for the measurement of tumour interstitial pressure in conscious unrestrained rats and mice (2003). Currently, he is the 3R’s representative for Oncology Basel at Novartis.
First Name
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Email Address
Job Title
Organization
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Main area of research:
Animal Behavior
Biotechnology- Antibodies, protein and peptide delivery
Cancer Research
Cardiovascular Science
Endocrinology
Gene Therapy
Immunology
Infectious Diseases
Neuroscience
Pharmacology
Physiology
Toxicology
Work with SCID Mice
Vaccines
ICV Delivery in Mice
Other
What animal models do you work with?
Mice
Rats
Rabbits
Guinea Pigs
Canines
NHP
Other
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