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A New Frontier of Precision Medicine: Using PET for Image-Guided Neurointerventions

Live date:Thursday, May 7, 2020

Start Time:11:00 AM EDT

Duration:60 minutes

Abstract:

Mice are by far the most frequently used animal for modeling disease and developing therapeutic strategies including neurointerventions. However, due to its anatomical and physiological barriers, the brain is a difficult target for delivery of therapeutic agents. Systemic administration is plagued with marginal brain accumulation and high risk of off-target side effects.

In this webinar sponsored by Scintica Instrumentation, Dr. Piotr Walczak, Dr. Mirosław Janowski and Dr. Wojciech Lesniak will address this challenge and discuss why advanced imaging is essential to perform image-guided neurointerventions.

First, Dr. Janowski will provide rationale as to how imaging can be used to better understand how therapeutic agents are delivered to the brain and subsequently cleared. Next, Dr. Walczak will review methodological and technological advances for improving precision and reproducibility of brain targeting in mice based on MRI and two-photon microscopy. Finally, Dr. Lesniak will present recently-published results using ARGUS PET/CT to quantify intra-artrial delivery of antibodies, nanobodies and poly(amidoamine) dendrimers.

Key discussion topics will include:
  • Why advanced imaging is essential to perform image-guided neurointerventions
  • Why we need to visualize not only penetration of therapeutic agents to the brain but also their clearance
  • How image-guided procedures can be used to visualize and optimize delivery of therapeutic agents to the brain

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Speakers

Miroslaw Janowski

Associate Professor

University Of Maryland, Baltimore

Dr. Janowski’s background in clinical neurosurgery, neuroscience and imaging provides an excellent basis for studying diseases of the central nervous system. Early in his career he recognized a peculiarity of the brain and spinal cord, which are hidden behind the skull and blood brain barrier. Much progress has been made in the treatment of many diseases, while therapeutic outcomes of brain disorders lag behind. Therefore, his current focus is on the development of methods for effective delivery of therapeutic agents to the brain, and advanced imaging is pivotal for proper understanding of therapeutic agent kinetics, including delivery and clearance from the brain.

Piotr Walczak, MD, PhD

Professor, Diagnostic Radiology and Nuclear Medicine

University of Maryland School of Medicine

Dr. Walczak received his medical degree from the Medical University of Warsaw and a PhD in regenerative medicine from the University of Warmia and Mazury in Poland, followed by postdoctoral training at the University of South Florida and the Johns Hopkins University. He served on a faculty at Hopkins until 2019 when he joined UMB Department of Diagnostic Radiology and Nuclear Medicine. His research focuses on developing advanced tools for guiding brain repair strategies. His lab utilizes animal models and multimodal imaging to interrogate mechanisms and improve efficacy of therapeutic agents such as stem cells, macromolecules and gene therapeutics.

Wojciech Lesniak, PhD

Research Associate, Department of Radiology

Johns Hopkins School of Medicine

Dr. Wojciech Lesniak earned a M.Sc. in Chemistry and PhD in Bioinorganic Biomedical Chemistry at the University of Wroclaw and completed post-doctoral training at the University of Michigan in the Department of Chemistry and the Center of Nanotechnology for Medicine. Since 2012, he has been working at the Johns Hopkins School of Medicine in the Department of Radiology, and since 2019 he has served as Director of the Radiometabolite Laboratory at PET center. He has been involved in multidisciplinary research related to development and evaluation of low molecular weight scaffolds, nanoparticles and theranostic agents for targeted cancer imaging and therapy.
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