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Animal Model Selection, Study Design and Current Trends in Preclinical Obesity Research

live Date:Wed. September 30, 2020

Duration:45 minutes

During this presentation, Dr. Fred Beasley gives a broad-level overview of the factors to consider when deciding on an appropriate preclinical rodent model for studying obesity and its treatments. It features an overview of trends in obesity and associated illnesses, and the role of pharmacological intervention. Dr. Beasley discusses criteria for establishing a study’s aims and review commonly used rodent models obesity, addressing both genetically inherited and diet-induced obesity. The webinar concludes with additional considerations for improving your study design.

Key topics include…

  • An introduction to the role of pharmacological intervention in treating obesity
  • A guide to establishing study aims for obesity research
  • An overview of commonly used rodent obesity models (diet and genetic)
  • Additional considerations for obesity research study design

Key methods reviewed include…

Pharmacotherapy, diet induced obesity, Western-style diet, monogenic obese rodents, polygenic obese rodents, NAFLD activity score

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Fred Beasley, PhD

Director of Scientific Engagement – Cardiovascular and Metabolic Disease

Crown Bioscience

As Director of Scientific Engagement for the Cardiovascular and Metabolic Disease Division at Crown Bioscience, Dr. Fred Beasley has extensive experience with the development of animal models, the design and execution of research projects and with client/operations communications. Before he was with CrownBio, Fred served as in vivo biologist at the NASH/inflammation startup Jecure Therapeutics and as a Study Director at BTS Research, Southern California’s sole provider of preclinical NHP models. Fred obtained his PhD in Microbiology and Immunology at the University of Western Ontario and completed postdoctoral training at UC San Diego and at Calibr/Scripps Research Institute. His research focus is the development of animal models to evaluate small molecule drugs against bacterial and parasitic pathogens, and he is an author on over 20 publications.
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