3D Biomatrix

About the Event

Date: Tuesday, October 8, 2013
Time: 10:30 AM EST; 3:30 UK time (GMT+1h)
Duration: 60 Minutes

Two-dimensional (2D) cell cultures have provided a number of breakthroughs for understanding human tissues and diseases, as well as for discovering and testing new drugs. However, 2D cell cultures have limitations, such as limited cell-cell and cell-matrix contacts, flat cellular morphologies and a lack of realistic mass transfer gradients. As a result, technologies that facilitate growing cells in three-dimensional (3D) configurations have been developed to make cellular behaviors in vitro better resemble the body.

This webcast will explore the potential of 3D cell-based models for regenerative medicine and drug discovery and features presentations from two leading experts in the field.

3D Cell-Based Models for Regenerative Medicine and Drug Discovery By Elad Katz, PhD, AMSBIO

To fulfill the increased demand for 3D cell cultures, AMSBIO supplies the most advanced and extensive range of 3D tools to the life science community. Elad Katz, PhD, assesses the impact on the physiological relevance of in vitro cell based models using traditional ECM proteins, alvetex scaffolds and low adhesion plates in drug discovery and disease modeling applications. Highlighting examples including oncology and stem cell culture, Dr Katz will demonstrate how the different 3D technologies that AMSBIO provides can help researchers to successfully perform the applications they need. Drug discovery considerations such as suitability for high-throughput screening will be discussed in detail.

Novel 3D Culture Technologies for Drug Development By Jean-Louis Klein, PhD, GlaxoSmithKline

Drug attrition is a major challenge facing the pharmaceutical industry. Most of the compounds entering clinical trials will not end up as marketed drugs. Toxicity and lack of efficacy are the main reasons for the failures, telling us that preclinical models are not adequately effective in predicting the effects of novel drugs in humans. Novel culture technologies, such 3D, medium flow or share forces and co-culture have the potential to better mimic the in vivo physiology and therefore to better predict patient responses to novel drugs versus classical 2D culture. Examples of 3D spheroid assays using Perfect3D Hanging Drop plates (3D Biomatrix) will illustrate that 3D spheroid technologies can be easily incorporated into early phases of drug discovery.

 

 

3D Cell-Based Models for Regenerative Medicine and Drug Discovery

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